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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Jun 2026 · 1 min read
In brief
In brief
Neuroblastoma is the most common extracranial solid tumor in children, typically arising in the adrenal glands or along neural crest pathways. Treatment is risk-stratified, ranging from observation for low-risk lesions to intensive multimodal therapy for high-risk disease, with surgical resection playing a key role in local control.
Written by the GCMD Library team from the article.
Statements in this article
Neuroblastoma is the most common extracranial pediatric solid tumor.
The most common location for development of neuroblastoma is in the adrenal glands.
Primary neuroblastoma tumors may develop along the developmental pathway of neural crest progenitor cells.
Neuroblastoma may vary in severity and prognosis from low-risk congenital neuroblastic lesions to aggressive high-risk neuroblastoma.
Therapy for neuroblastoma is risk-based with intensification of therapy for those at greater risk and de-escalation for patients with lower risk tumors.
Surgical resection has a critical role in local control of neuroblastoma for the most optimal outcome.