Neonatal and fetal therapy of congenital diaphragmatic hernia-related pulmonary hypertension
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Feb 2022 · 1 min read
In brief
In brief
Comprehensive review of therapeutic approaches for pulmonary hypertension in congenital diaphragmatic hernia, covering both neonatal management strategies and prenatal interventions. Discusses current clinical therapies and emerging experimental treatments targeting the pathophysiology of CDH-related pulmonary hypertension.
Written by the GCMD Library team from the article.
Congenital diaphragmatic hernia (CDH) is a complex malformation characterised by a triad of pulmonary hypoplasia, pulmonary hypertension (PH) and cardiac ventricular dysfunction. Much of the mortality and morbidity in CDH is largely accounted for by PH, especially when persistent beyond the neonatal period and refractory to available treatment. Gentle ventilation, haemodynamic optimisation and pulmonary vasodilation constitute the foundations of neonatal treatment of CDH-related PH (CDH-PH). Moreover, early prenatal diagnosis, the ability to assess severity and the developmental nature of the condition generate the perfect rationale for fetal therapy. Shortcomings of currently available clinical therapies in combination with increased understanding of CDH pathophysiology have spurred experimental drug trials, exploring new therapeutic mechanisms to tackle CDH-PH. We herein discuss clinically available neonatal and fetal therapies specifically targeting CDH-PH and review the most promising experimental treatments and future research avenues.
DOI: 10.1136/archdischild-2021-322617