Long-term pulmonary function after lobectomy for congenital pulmonary airway malformation: is thoracoscopic approach really better than open?
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In brief
In brief
Comparative study of 24 CPAM patients shows thoracoscopic lobectomy results in superior long-term pulmonary function compared to open approach, with significantly better FVC, FEV1, and diffusion capacity at 7+ years post-operation. Findings suggest thoracotomy may impair respiratory musculature development in pediatric patients.
Written by the GCMD Library team from the article.
Introduction
Congenital pulmonary airway malformation (CPAM) is the most common lung pathology diagnosed antenatally. Thoracoscopic lobectomy has shown increasing popularity, but the long-term result is still lacking. In this study we compared long -term pulmonary function after thoracoscopic and open lobectomy.
Methods
All CPAM patients with lobectomy between 2000 and 2008 were recruited into the study. Pulmonary function test (PFT) was performed at least 7 years after operation. Demographic data and PFT results were analyzed. Comparison was made between the thoracoscopic and open group.
Results
Twelve patients were included in each group. PFT was performed at a mean age of 9.8 (thoracoscopic) and 12.2 years (open), respectively (p = 0.17). The thoracoscopic group showed better performance in forced vital capacity (FVC) (98.9 vs 84.3% predicted, p = 0.03), forced expiratory volume in 1 s (FEV1) (88.5 vs 76.1% predicted, p = 0.04), and alveolar volume adjusted diffusion capacity of carbon monoxide (106.4 vs 91.4% predicted, p = 0.03). FEV1 to FVC ratio, total lung capacity, and residual volume showed no statistical difference.
Conclusion
The long term PFT result following thoracoscopic lobectomy is better than open lobectomy. This may be due to impaired respiratory musculature after thoracotomy. Further study with larger sample size is necessary to determine this hypothesis.
Level-of-evidence
III