Kurtosis and skewness of high-frequency brain signals are altered in paediatric epilepsy.
pubmed.ncbi.nlm.nih.gov shows its articles on its own site.
Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Nov 2026 · 1 min read
In brief
In brief
This study demonstrates that statistical analysis of high-frequency brain signals (80-600 Hz) using kurtosis and skewness measurements can noninvasively identify epileptogenic zones in children with drug-resistant epilepsy. The MEG-based approach achieved 96% localization accuracy compared to invasive recordings and surgical outcomes, offering a potential alternative to intracranial monitoring for presurgical evaluation.
Written by the GCMD Library team from the article.
Intracranial studies provide solid evidence that high-frequency brain signals are a new biomarker for epilepsy. Unfortunately, epileptic (pathological) high-frequency signals can be intermingled with physiological high-frequency signals making these signals difficult to differentiate. Recent success in non-invasive detection of high-frequency brain signals opens a new avenue for distinguishing pat…
Educational content from recorded physician discussions — not medical advice. Talk to your (or your child's) care team about your situation.
Article
Fosphenytoin pre-medication for pediatric extra-operative electrical stimulation brain mapping.
Francesco T. Mangano · Published Nov 2026
Article
Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation.
Francesco T. Mangano · Published Nov 2026
Article
Subdural grid and depth electrode monitoring in pediatric patients.
Francesco T. Mangano · Published Nov 2026
Article
Pediatric Epilepsy Surgery: The Prognostic Value of Central Nervous System Comorbidities in Patients and their Families.
Francesco T. Mangano · Published Nov 2026
Article
Seizures following surgery for supratentorial extratemporal low-grade tumors in children: a multicenter retrospective study.
Francesco T. Mangano · Published Nov 2026
Article
Investigation of bias in an epilepsy machine learning algorithm trained on physician notes.
Francesco T. Mangano · Published Nov 2026
Article
Diffusion tensor imaging in children following prenatal myelomeningocele repair and its predictive value for the need and timing of subsequent CSF diversion surgery for hydrocephalus.
Francesco T. Mangano · Published Nov 2026
Article
Empiric Antibiotic Prescription Patterns in Children With Cerebrospinal Fluid Shunt Infection.
Francesco T. Mangano · Published Nov 2026
Article
Pediatric Hydrocephalus and the Primary Care Provider.
Francesco T. Mangano · Published Nov 2026
Article
White matter characteristics in children with cerebral palsy prior to selective dorsal rhizotomy: a multicenter diffusion tensor imaging study.
Francesco T. Mangano · Published Nov 2026
Article
A probabilistic approach for lateralization of seizure onset zone in drug-resistant epilepsy with bilateral cerebral pathology.
Francesco T. Mangano · Published Nov 2026
Article
Posterior Quadrant Disconnection Procedure for Intractable Epilepsy: A Case Series of 5 Young Pediatric Patients.
Francesco T. Mangano · Published Nov 2026