Intellectual development of patients with biliary atresia who underwent living donor liver transplantation in infancy
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In brief
In brief
Study of 20 school-aged patients who underwent living donor liver transplantation for biliary atresia in infancy reveals mean IQ significantly lower than general population (91.8 vs 100), with 35% showing borderline intellectual functioning. Findings highlight need for long-term neurodevelopmental monitoring in this patient population.
Written by the GCMD Library team from the article.
Abstract
Background
The impact of pediatric liver transplantation on intellectual development has yet to be determined. We investigated the intellectual outcomes of school-aged patients after living donor liver transplantation for biliary atresia in infancy.
Methods
The Wechsler Intelligence Scale for Children—fourth edition test was administered to 20 patients who survived \(\ge \) 5 years after living donor liver transplantation. Borderline full scale intelligence quotient was defined as ≤ 85. Pre-, peri-, and postoperative data were compared between patients with > 85 and ≤ 85 to identify predictive factors of borderline performance.
Results
The one-sample t test demonstrated that the mean full scale intelligence quotient of patients after transplantation for biliary atresia was significantly lower than that of the general population (91.8 vs. 100.0, p = 0.026) and 7 (35%) were classified as intellectual borderline functioning. Multivariable logistic regression models were unable to identify any factors predictive of full scale intelligence quotients of ≤ 85.
Conclusion
This is the first study to indicate that the mean full scale intelligence quotient among school-aged patients who underwent living donor liver transplantation for biliary atresia in infancy is significantly lower than that of the general population.