Dr. Nelson G. Rosen · Impact of Trisomy 21 on post pull-through enterocolitis and bowel function in children with Hirschsprung disease: A PCPLC analysis.
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Article1 min read·Published Nov 2026

Impact of Trisomy 21 on post pull-through enterocolitis and bowel function in children with Hirschsprung disease: A PCPLC analysis.

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Article · Nov 2026 · 1 min read

In brief

In brief

Multi-center study examining how Trisomy 21 affects post-operative outcomes in children with Hirschsprung disease, specifically analyzing rates of enterocolitis, bowel management needs, and toilet training success. Findings inform clinical expectations and counseling for families of children with both conditions.

Written by the GCMD Library team from the article.

Nelson G. Rosen

We evaluated whether Trisomy 21 (T21) affected bowel management use, ability to toilet train for stool, and rates of Hirschsprung-Associated Enterocolitis (HAEC) in children with Hirschsprung disease (HD). We hypothesized that T21 would be associated with increased rates of HAEC, bowel management program (BMP) use, and delayed toilet training for stool. Children with HD in the Pediatric Colorectal…

Statements in this article

  1. The study evaluated whether Trisomy 21 affected bowel management use, ability to toilet train for stool, and rates of Hirschsprung-Associated Enterocolitis in children with Hirschsprung disease.

    Research
  2. The hypothesis was that Trisomy 21 would be associated with increased rates of HAEC, bowel management program use, and delayed toilet training for stool.

    Research

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