Health-Related Quality of Life in Biliary Atresia Patients with Native Liver or Transplantation
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In brief
In brief
This study evaluates health-related quality of life in biliary atresia patients aged 6-16 years, comparing those with native liver versus transplant recipients. Dutch BA patients showed significantly lower physical quality of life compared to healthy peers, with findings consistent across international literature.
Written by the GCMD Library team from the article.
Introduction We aimed to assess health-related quality of life (HrQoL) in biliary atresia (BA) patients, based on original data and a literature review, and to determine factors associated with their HrQoL.
Materials and Methods We reviewed available studies describing HrQoL in BA patients. We assessed HrQoL in Dutch BA patients (6–16 years) using the validated Child Health Questionnaire. We compared HrQoL scores in BA patients with healthy peers and with children who had undergone major surgery in infancy or children with chronic conditions. We determined the relationship between specific patient-related factors and HrQoL.
Results Literature data indicated that HrQoL in children with BA is lower than in healthy peers. In Dutch BA patients (n = 38; age 10 ± 3 years), parent-proxy physical HrQoL (48 ± 11) was significantly lower compared with two reference groups of healthy peers (59 ± 4 and 56 ± 6, respectively, each p