Epidemiological characteristics of Hirschsprung’s disease (HSCR): Results of a case series of fifty patients from Bangladesh
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In brief
In brief
Prospective study of 50 Hirschsprung disease patients in Bangladesh found elevated consanguinity rates (16% vs 10% general population) and no association with advanced maternal age. Most patients were born at term with normal birth weight, and 18% had associated anomalies including two previously unreported coexisting conditions.
Written by the GCMD Library team from the article.
Background
The epidemiology of Hirschsprung's disease (HSCR) in Bangladesh has never been studied. The aim of this study was to determine the epidemiological characteristics of HSCR in Bangladesh.
Methods
Data from fifty patients were collected prospectively from two hospitals in Chittagong, Bangladesh.
Results
The rate of consanguinity (16%) among parents of HSCR patients was higher than that of the general population (10%). Maternal age at the time of birth of the affected child was ≤30years in all cases except one. No association was found between parents' occupation and HSCR. No patient was born preterm and only three patients (6%) had low birth weight. Nine patients (18%) had associated anomalies. We found coexistence of bilateral accessory tragi and ankyloglossia in one patient, and coexistence of rectal duplication cyst in another. Neither anomaly had been previously reported in HSCR patients.
Conclusions
Our study suggests that consanguinity might increase the risk of HSCR whereas advanced maternal age does not. HSCR patients were found more likely to born at term and with normal birth weight. The coexistence of HSCR with previously unreported anomalies highlights the diversity of conditions that can co-occur with HSCR.
Levels of evidence
IV