Customized postoperative therapy improves bile drainage in biliary atresia: A single center preliminary report
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Feb 2023 · 1 min read
In brief
In brief
This single-center study demonstrates that customized postoperative protocols using tailored antibiotics and corticosteroids significantly improved bile drainage success after hepatoportoenterostomy for biliary atresia, with 80% achieving drainage versus 40% in historical controls. The approach shows promise for optimizing outcomes in this challenging condition.
Written by the GCMD Library team from the article.
Background: Controversies in management of biliary atresia (BA) after hepatoportoenterostomy (HPE) lead to variable treatment protocols. We implemented standardized medical management after HPE, customizing the use of antibiotics and corticosteroids based on patient-specific factors.
Methods: In this retrospective analysis, 20 consecutive infants underwent HPE for BA and were compared to a historical cohort. Analysis of successful biliary drainage 3 months after HPE (defined as serum total bilirubin <2 mg/dL) was the primary endpoint; survival with native liver at 2 years was the secondary endpoint.
Results: Sixteen of 20 (80%) infants had successful bile drainage, compared to 8 of 20 (40%) infants in the historical cohort (P = 0.0225). Sixteen of 20 patients in the new protocol have reached 2 years of age or required liver transplantation. Among the sixteen, 11 (68.8%) are alive with native livers versus 10 of 20 (50%) in the historical cohort (P = 0.0970).
Conclusion: This preliminary report suggests the potential benefit of tailored use of postoperative antibiotics and corticosteroids in improving biliary drainage after HPE.
DOI: 10.1016/j.jpedsurg.2022.10.050