Congenital diaphragmatic hernia: Exclusion criteria for repair or ECMO?

jpedsurg.org

Mortality in congenital diaphragmatic hernia (CDH) approximates 30 %. Both severe lung hypoplasia and other anomalies contribute to demise regardless of repair and/or extracorporeal membrane oxygenation (ECMO). We report clinical and physiological parameters for CDH infants not offered repair or ECMO (NoR/ECMO).

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Article · Oct 2025 · 1 min read

In brief

This study examines clinical and physiological parameters used to identify CDH infants who are not candidates for surgical repair or ECMO support. With CDH mortality around 30%, the research focuses on defining exclusion criteria based on severe lung hypoplasia and associated anomalies that predict poor outcomes despite intervention.

CDH mortality remains approximately 30% despite advances in surgical and ECMO support
Severe lung hypoplasia is a primary contributor to mortality independent of intervention
Associated congenital anomalies significantly impact survival outcomes in CDH patients
Clinical and physiological parameters can identify infants unlikely to benefit from repair or ECMO
Establishing exclusion criteria helps guide appropriate resource allocation and family counseling

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