Francesco T. Mangano · Clinical factors predict surgical outcomes in pediatric MRI-negative drug-resistant epilepsy.

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From Dr. Francesco T. Mangano

Article1 min read·Published Nov 2026

Clinical factors predict surgical outcomes in pediatric MRI-negative drug-resistant epilepsy.

Part of Pediatric Epilepsy Surgery 85 items

pubmed.ncbi.nlm.nih.gov

Clinical factors predict surgical outcomes in pediatric MRI-negative drug-resistant epilepsy.

Francesco T. Mangano

Lack of a potentially epileptogenic lesion on brain magnetic resonance imaging (MRI) is a poor prognostic marker for epilepsy surgery. We present a single-center series of childhood-onset MRI-negative drug-resistant epilepsy (DRE) and analyze surgical outcomes and predictors. Children with MRI-negative DRE who had resective surgery from January 2007 to December 2013 were identified using an instit…

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Article · Nov 2026 · 1 min read

In brief

In brief

This study examines surgical outcomes in children with drug-resistant epilepsy who lack visible brain lesions on MRI—a traditionally poor prognostic indicator. Analyzing resective surgery cases from 2007-2013, researchers identify clinical factors that predict which MRI-negative patients may still benefit from surgical intervention.

Written by the GCMD Library team from the article.

Francesco T. Mangano

Lack of a potentially epileptogenic lesion on brain magnetic resonance imaging (MRI) is a poor prognostic marker for epilepsy surgery. We present a single-center series of childhood-onset MRI-negative drug-resistant epilepsy (DRE) and analyze surgical outcomes and predictors. Children with MRI-negative DRE who had resective surgery from January 2007 to December 2013 were identified using an instit…

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