Clinical controversies in anticoagulation monitoring and antithrombin supplementation for ECMO

In brief

This review examines the clinical challenges of anticoagulation management during pediatric and neonatal ECMO, focusing on the controversial use of antithrombin supplementation for heparin resistance. The authors address practice variability stemming from limited evidence, developmental hemostatic differences, and the difficulty of balancing thrombotic versus bleeding risks in critically ill children.

Written by the GCMD Library team from the article.