Francesco T. Mangano · Behavior-iEEG-Spectral-Power-Correlation: Defining Neural Substrates of Naturalistic Behavior.
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Article1 min read·Published Nov 2026

Behavior-iEEG-Spectral-Power-Correlation: Defining Neural Substrates of Naturalistic Behavior.

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Article · Nov 2026 · 1 min read

In brief

In brief

This study introduces BESPoC, a novel methodology for language localization using naturalistic conversation rather than artificial repetitive tasks during intracranial EEG monitoring. The approach offers a more patient-friendly alternative to traditional electrical stimulation and high-gamma mapping techniques for presurgical language mapping in epilepsy patients.

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Francesco T. Mangano

Intracranial language localization with electrical stimulation mapping (ESM) and high-gamma modulation (HGM) mapping relies on artificial, repetitive tasks, requiring sustained cooperation from patients. Herein, we tested the validity of unstructured, interpersonal, naturalistic conversation for language localization, using a novel methodology: Behavior-iEEG-Spectral-Power correlation (BESPoC). We…

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