Autism spectrum disorder and neurodevelopmental delays in children with giant omphalocele
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Read the article on jpedsurg.org ↗Article · Jun 2019 · 1 min read
In brief
In brief
Study of 47 giant omphalocele survivors reveals autism spectrum disorder prevalence 16 times higher than general population, with increased risk of neurodevelopmental delays and genetic abnormalities. Findings emphasize need for long-term developmental surveillance in this surgical population.
Written by the GCMD Library team from the article.
Objective
To determine the prevalence and identify risk factors of autism spectrum disorders (ASDs) and neurodevelopmental delays in giant omphalocele (GO) survivors.
Materials and methods
The study cohort consists of 47 GO survivors enrolled in our follow-up program between 07/2004 and 12/2015. All patients underwent assessments at 2 years of age or older. Outcomes were assessed by either the Bayley Scales of Infant Development II (prior 2006) or III (after 2006), or the Wechsler Preschool and Primary Scale of Intelligence (children older than 4 years). ASD diagnosis was made based on the Diagnostic and Statistical Manual of Mental Disorders IV (prior to 2014) or 5 criteria.
Results
The prevalence of ASD in GO children is 16 times higher than the general population (P = 0.0002). ASD patients were more likely to be diagnosed with neurodevelopmental and neurofunctional delays, language disorders, and genetic abnormalities (P