A Comparison of Commonly Utilized Diagnostic Biopsy Techniques for Pediatric Patients With Cancer: A Systematic Review by the APSA Cancer Committee

jpedsurg.org

Historically, surgical biopsy (SB) for diagnosis of pediatric solid tumors was considered necessary to provide adequate tissue for histologic and molecular analysis. Less invasive biopsy techniques such as image-guided core needle biopsy (CNB), have shown comparable accuracy with decreased morbidity in some adult studies. However, data regarding the safety and efficacy of CNB in pediatric tumors is limited. This study's aim was to assess the overall rate of successful diagnosis and safety of CNB compared to SB in children with malignancies.

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Article · Sep 2024 · 1 min read

In brief

This systematic review by the APSA Cancer Committee compares image-guided core needle biopsy to traditional surgical biopsy for diagnosing pediatric solid tumors. The study evaluates diagnostic accuracy and safety profiles of both techniques to determine whether less invasive approaches can adequately replace open surgical procedures in children with cancer.

Image-guided core needle biopsy (CNB) offers a less invasive alternative to surgical biopsy for pediatric solid tumor diagnosis.
CNB has demonstrated comparable diagnostic accuracy to surgical biopsy with reduced morbidity in adult populations.
Pediatric-specific data on CNB safety and efficacy remains limited, highlighting a gap in evidence-based practice.
Adequate tissue acquisition for both histologic and molecular analysis is achievable with minimally invasive techniques.
Systematic comparison of biopsy methods can guide optimal diagnostic approaches in pediatric oncology.

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