Serum Lactate Clearance as a Predictive Biomarker for Optimal Graft Perfusion in Living Donor Liver Transplantation

In brief

This study examines lactate clearance as a biomarker to assess the relationship between graft volume and portal venous flow in living donor liver transplantation. By analyzing perioperative lactate levels, researchers aim to predict early graft dysfunction and optimize perfusion balance for improved transplant outcomes.

• Lactate clearance serves as a functional biomarker for graft perfusion quality in living donor liver transplantation.
• Portal venous flow relative to graft volume impacts early graft function and can be monitored via lactate metabolism.
• Perioperative lactate levels help identify early graft dysfunction before clinical manifestations appear.
• Optimal graft-to-flow ratio remains undefined; lactate tracking may guide intraoperative hemodynamic management.
• Hepatic lactate metabolism reflects real-time graft metabolic capacity in the immediate post-transplant period.

Written by the GCMD Library team from the article.