Systemic inflammation enhances metastatic growth in a syngeneic neuroblastoma mouse model
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In brief
In brief
Mouse model study demonstrates that systemic inflammation, rather than surgical resection itself, drives metastatic neuroblastoma growth. Sponge implantation produced higher CRP and IL-6 levels with increased lymph node and lung metastases compared to partial resection or observation groups, suggesting inflammatory response as key mechanism.
- Systemic inflammation from surgical trauma (sponge implantation) increased lymph node metastasis volume 14-fold vs observation in neuroblastoma mice
- Inflammatory markers CRP and IL-6 were significantly elevated in mice with sponge implants compared to partial resection or observation groups
- Surgical inflammation alone, independent of tumor resection, enhanced both lymph node and lung metastasis frequency in this neuroblastoma model
- Minimizing perioperative systemic inflammation may be a therapeutic target to reduce metastatic progression after neuroblastoma surgery
Written by the GCMD Library team from the article.
Abstract
Background
We previously showed that total tumor resection enhances metastatic growth in a syngeneic metastatic mouse model of neuroblastoma. In this study, we further investigated which surgical factors contributed most to metastatic growth.
Methods
Tumor cells derived from MYCN transgenic mice were subcutaneously injected into wild-type mice. Mice were randomly assigned to receive partial resection (PR group), subcutaneous implantation of a sponge (Sp group), or observation (Obs group). The lymph node metastasis volume and the frequency of lung metastasis were compared 14 days after assignment by measuring C-reactive protein (CRP) and interleukin-6 (IL-6) levels.
Results
The lymph node metastasis volume in the Sp group was larger than in the Obs group (148.4 [standard deviation {SD}: 209.5] vs. 10.2 [SD 12.8] mm3). The frequency of lung metastasis was greater in the Sp group than in the PR group (11.9 [SD 12.2] vs. 6.6 [SD 4.0] counts/slide). The CRP level in the Sp group was higher than in the PR group (2.3 [SD 0.5] vs. 1.5 [SD 0.4] μg/mL), and the IL-6 level in the Sp group was higher than in the PR or Obs groups (28.4 [SD 34.5] vs. 12.4 [SD 19.0] vs. 5.4 [SD 8.1] pg/mL).
Conclusion
Metastatic growth may be enhanced by systemic inflammation.