Safety and efficacy of mucous fistula refeeding in low-birth-weight infants with enterostomies
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In brief
In brief
Retrospective study of low-birth-weight infants with enterostomies demonstrates that mucous fistula refeeding significantly improves weight gain and reduces parenteral nutrition duration without complications. The technique potentially decreases PN-associated liver disease incidence.
Written by the GCMD Library team from the article.
Abstract
Purpose
To investigate the safety and efficacy of mucous fistula refeeding (MFR) in low-birth-weight infants.
Methods
Between December 2006 and December 2018, medical records of low-birth-weight infants who underwent small bowel enterostomy formation in the neonatal period and subsequent stoma closure at our institution were retrospectively reviewed. Patients were assigned to “refeeding” (RF) and “non-refeeding” (NRF) groups, which were compared for patient characteristics and clinical outcomes. We also cultured the proximal stoma output over time in the RF group and reviewed changes in the flora to evaluate the safety of refeeding.
Results
In the RF group, compared with that before refeeding, there was significantly more rapid weight gain after refeeding (17.7 vs 10.6 g/day; P = 0.002). Median total time of parenteral nutrition (PN) was 25 and 87 days in the RF and NRF groups, respectively (P = 0.001). The number of patients who developed PN-associated liver disease (PNALD) was smaller in the RF group (P = 0.12). No complications of MFR were noted and no pathogenic bacteria were cultured.
Conclusion
MFR was able to diminish the need for PN, which potentially decreased the incidence of PNALD, and was safe as there were no complications of the refeeding process.