From
Dr. Alexander Bondoc
EZH2 is a key component of hepatoblastoma tumor cell growth.
pubmed.ncbi.nlm.nih.gov shows its articles on its own site.
Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Oct 2026 · 1 min read
In brief
In brief
This research investigates EZH2's role in hepatoblastoma tumor growth through both canonical histone methylation and noncanonical protein interactions. The study explores EZH2 as a therapeutic target in this pediatric liver malignancy, examining mechanisms beyond its traditional epigenetic function.
Written by the GCMD Library team from the article.
Enhancer of zeste homolog 2 (EZH2) catalyzes the trimethylation of histone H3 at lysine 27 via the polycomb recessive complex 2 (PRC2) and plays a time-specific role in normal fetal liver development. EZH2 is overexpressed in hepatoblastoma (HB), an embryonal tumor. EZH2 can also promote tumorigenesis via a noncanonical, PRC2-independent mechanism via proto-oncogenic, direct protein interaction, i…
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