Alberto Tozzi · Hepatitis B immune memory in children primed with hexavalent vaccines and given monovalent booster vaccines: an open-label, randomised, controlled, multicentre study.

From Dr. Alberto Tozzi

Article1 min read·Published Oct 2026

Hepatitis B immune memory in children primed with hexavalent vaccines and given monovalent booster vaccines: an open-label, randomised, controlled, multicentre study.

pubmed.ncbi.nlm.nih.gov

Hepatitis B immune memory in children primed with hexavalent vaccines and given monovalent booster vaccines: an open-label, randomised, controlled, multicentre study.

Alberto Tozzi

In 2000, hexavac and infanrix hexa were licensed in Europe for primary immunisation of children against diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and invasive infections caused by Haemophilus influenzae b. In 2005, hexavac was suspended because of concerns about the long-term immunogenicity of its hepatitis B component. We aimed to assess the duration of immunity and need for boo…

pubmed.ncbi.nlm.nih.gov shows its articles on its own site.

Read the article on pubmed.ncbi.nlm.nih.gov ↗

Article · Oct 2026 · 1 min read

In brief

In brief

This multicentre trial evaluated long-term hepatitis B immunity in children who received hexavalent vaccines (Hexavac or Infanrix Hexa) during primary immunization, following Hexavac's 2005 suspension due to immunogenicity concerns. The study assessed immune memory persistence and booster response to determine optimal vaccination strategies for sustained protection.

Written by the GCMD Library team from the article.

Alberto Tozzi

In 2000, hexavac and infanrix hexa were licensed in Europe for primary immunisation of children against diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, and invasive infections caused by Haemophilus influenzae b. In 2005, hexavac was suspended because of concerns about the long-term immunogenicity of its hepatitis B component. We aimed to assess the duration of immunity and need for boo…

Read it at the source ↗

Try

Intelligent Search· scoped to this article · not medical adviceSearch the whole library →

More from this author

Dive deeper → Dr. Alberto Tozzi

A cohort study of a tailored web intervention for preconception care.

Alberto Tozzi · Published Oct 2026

[Obesity and cardiovascular risk in children].

Alberto Tozzi · Published Oct 2026

Le funzioni e gli usi dell'intelligenza artificiale per la salute

Alberto Tozzi · 14 min · Published Oct 2026

Data to impact: connecting the future of European pediatrics with Alberto Tozzi

Alberto Tozzi · 20 min · Published Oct 2026

Towards learning healthcare systems in Italy: opportunities and challenges of AI at point-of-care.

Alberto Tozzi · Published Oct 2026

Methicillin-resistant Staphylococcus aureus nasal colonization in a department of pediatrics: a cross-sectional study.

Alberto Tozzi · Published Oct 2026