Alberto Tozzi · Preserved antibody levels and loss of memory B cells against pneumococcus and tetanus after splenectomy: tailoring better vaccination strategies.

From Dr. Alberto Tozzi

Article1 min read·Published Oct 2026

Preserved antibody levels and loss of memory B cells against pneumococcus and tetanus after splenectomy: tailoring better vaccination strategies.

pubmed.ncbi.nlm.nih.gov

Preserved antibody levels and loss of memory B cells against pneumococcus and tetanus after splenectomy: tailoring better vaccination strategies.

Alberto Tozzi

Splenectomized patients are exposed to an increased risk of septicemia caused by encapsulated bacteria. Defense against infection is ensured by preformed serum antibodies produced by long-lived plasma cells and by memory B cells that secrete immunoglobulin in response to specific antigenic stimuli. Studying a group of asplenic individuals (57 adults and 21 children) without additional immunologic …

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Article · Oct 2026 · 1 min read

In brief

In brief

This study examines immune responses in 78 splenectomized patients, revealing that while antibody levels against pneumococcus and tetanus remain intact, memory B cell populations are depleted. The findings suggest current vaccination protocols may need revision to address this specific immunologic gap in asplenic individuals.

Written by the GCMD Library team from the article.

Alberto Tozzi

Splenectomized patients are exposed to an increased risk of septicemia caused by encapsulated bacteria. Defense against infection is ensured by preformed serum antibodies produced by long-lived plasma cells and by memory B cells that secrete immunoglobulin in response to specific antigenic stimuli. Studying a group of asplenic individuals (57 adults and 21 children) without additional immunologic …

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