Using organoid platform to investigate the effect of smoking on congenital lung malformations

jpedsurg.org

Congenital lung malformation (CLMs) is a series of developmental lung abnormalities that may persist into adulthood. Some centres would advocate an observation approach rather than opting for surgical excision. However, the potential impact of environmental factors, particularly cigarette smoke exposure, on CLM-affected lung tissue remains poorly understood.

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Article · Mar 2026 · 1 min read

In brief

This study uses organoid platforms to examine how cigarette smoke affects congenital lung malformations (CLMs), addressing a critical knowledge gap for clinicians managing these developmental abnormalities. The research provides insights into environmental risk factors that may influence the watch-and-wait versus surgical approach debate in CLM management.

Congenital lung malformations (CLMs) are developmental abnormalities that can persist into adulthood.
Some centers favor observation over surgical excision for CLM management.
The impact of cigarette smoke exposure on CLM-affected lung tissue is not well understood.
Organoid platforms offer a novel approach to study environmental effects on congenital lung tissue.
Understanding smoking's effect on CLMs may inform clinical management decisions between observation vs surgery.

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