Unmasking Biliary Dyskinesia in Children Through Systematic Review and Meta- Analysis of 3,348 Patients Over the Last Two Decades

jpedsurg.org

Biliary dyskinesia (BD) is an increasingly common indication for pediatric cholecystectomy, but diagnostic criteria and outcomes remain debated. We conducted a systematic review and meta-analysis to evaluate symptom resolution, complications, and histopathology in children undergoing cholecystectomy for BD.

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Article · Nov 2025 · 1 min read

In brief

This meta-analysis examines outcomes in 3,348 pediatric patients who underwent cholecystectomy for biliary dyskinesia over 20 years, addressing ongoing controversies in diagnostic thresholds and treatment efficacy. The study synthesizes evidence on symptom resolution rates, surgical complications, and gallbladder histopathology to inform clinical decision-making in this increasingly common but debated indication for surgery in children.

- Biliary dyskinesia is now a leading indication for cholecystectomy in children, yet diagnostic criteria lack standardization. - Meta-analysis of 3,348 patients provides evidence-based benchmarks for symptom resolution rates after pediatric cholecystectomy. - Histopathology findings in BD cases can guide patient selection and inform preoperative counseling. - Complication rates from this large cohort establish safety profiles for cholecystectomy in the BD population. - Systematic review identifies gaps in current diagnostic approaches, informing future clinical practice guidelines.

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