Androgen Receptor Localization in Human Oral Mucosa: Implications for Hypospadias Surgery

jpedsurg.org

Hypospadias is a congenital defect of the urethra that often requires surgical correction. Oral mucosa (OM) is commonly used as a graft material in adult and pediatric urethroplasties (revised as suggested by Reviewer #3) , but its suitability for pediatric hypospadias surgery remains uncertain. A critical concern is whether OM grafts can grow proportionally with the penis during puberty, a process driven by androgen signaling. This study investigates androgen receptor (AR) localization and responsiveness in adult human OM to provide foundational insights for its potential clinical applications in hypospadias surgery.

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Article · Nov 2025 · 1 min read

In brief

This study examines androgen receptor distribution in adult oral mucosa to assess its viability as graft material for pediatric hypospadias repair. A key question is whether oral mucosa grafts can grow proportionally during puberty through androgen-mediated signaling, which would impact long-term surgical outcomes in children.

Oral mucosa is widely used in urethroplasty but its growth potential during puberty in hypospadias repair remains unclear.
Androgen receptor presence in oral mucosa is critical to determine if grafts can grow proportionally with penile development.
Study maps AR localization in adult oral mucosa to assess androgen responsiveness for pediatric hypospadias applications.
Understanding AR distribution may guide optimal graft selection and timing for hypospadias reconstruction in children.

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