Comparison of interventions in pediatric primary vesicoureteral reflux: A network meta-analysis

In brief

This network meta-analysis compares multiple treatment approaches for pediatric primary vesicoureteral reflux, including three surgical reimplantation techniques, three endoscopic injection methods, and antibiotic prophylaxis. The study aims to establish a comparative ranking of these interventions based on efficacy and safety outcomes to guide clinical decision-making in managing VUR in children.

• Multiple surgical reimplantation techniques exist for pediatric VUR: Lich-Gregoir, Politano-Leadbetter, and Cohen procedures.
• Endoscopic injection options include dextranomer/hyaluronic acid (Dx/HA), Macroplastiques, and polyacrylate-polyalcohol copolymer (PPC).
• Network meta-analysis provides comparative ranking of VUR treatments when head-to-head trials are limited.
• Treatment selection should balance efficacy and safety profiles across surgical, endoscopic, and medical management options.
• Antibiotic prophylaxis remains a conservative alternative to interventional approaches for primary VUR management.

Written by the GCMD Library team from the article.